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1

Emergence and treatment of multidrug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis in South Africa

Elizabeth M. Streicher, Borna Müller, Violet Chihota, Charmaine Mlambo, Marisa Tait, Manormoney Pillay, Andre Trollip, Kim G.P. Hoek, Frederick A. Sirgel, Nicolaas C. Gey van Pittius, Paul D. van Held

Journal:

Infection, Genetics and Evolution

Year:

2012

Language:

english

File:

PDF, 535 KB

english, 2012

2

Long-term outcomes of patients with extensively drug-resistant tuberculosis in South Africa: a cohort study

Pietersen, Elize, Ignatius, Elisa, Streicher, Elizabeth M, Mastrapa, Barbara, Padanilam, Xavier, Pooran, Anil, Badri, Motasim, Lesosky, Maia, van Helden, Paul, Sirgel, Frederick A, Warren, Robin, Dhed

Journal:

Year:

2014

Language:

english

File:

PDF, 486 KB

english, 2014

3

Monitoring the ingestion of anti-tuberculosis drugs by simple non-invasive methods

F.A. Sirgel, J.S. Maritz, A. Venter, G. Langdon, P.J. Smith, P.R. Donald

Journal:

International Journal of Pharmaceutics

Year:

2006

Language:

english

File:

PDF, 177 KB

english, 2006

4

The influence of dose andN-acetyltransferase-2 (NAT2) genotype and phenotype on the pharmacokinetics and pharmacodynamics of isoniazid

P. R. Donald, D. P. Parkin, H. I. Seifart, H. S. Schaaf, P. D. van Helden, C. J. Werely, F. A. Sirgel, A. Venter, J. S. Maritz

Journal:

European Journal of Clinical Pharmacology

Year:

2007

Language:

english

File:

PDF, 163 KB

english, 2007

5

Renylaima capensisn. gen., n. sp. (Trematoda: Brachylaimidae) from the urinary system of the shrewMyosorex variusSmuts, 1832 (Insectivora: Soricidae)

Willem F. Sirgel, Santiago Mas-Coma

Journal:

Parasitology Research

Year:

2010

Language:

english

File:

PDF, 430 KB

english, 2010

6

A New Ciliate Genus Trichodoxa n. g. (Ciliata, Peritricha, Mobilina, Trichodinidae) with Two New Species from the Genital System of Terrestrial Pulmonates

Journal:

Journal of Eukaryotic Microbiology

Year:

1983

Language:

english

File:

PDF, 2.79 MB

english, 1983

7

gyrA mutations and phenotypic susceptibility levels to ofloxacin and moxifloxacin in clinical isolates of Mycobacterium tuberculosis

Sirgel, F. A., Warren, R. M., Streicher, E. M., Victor, T. C., van Helden, P. D., Bottger, E. C.

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2012

Language:

english

File:

PDF, 179 KB

english, 2012

8

The early bactericidal activity of different dosages of isoniazid

P.R. Donald, F.A. Sirgel, F.J. Botha, B.W. van de Wal, D.P. Parkin, H.I. Seifart, D.A. Mitchison

Journal:

Tubercle and Lung Disease

Year:

1994

Language:

english

File:

PDF, 150 KB

english, 1994

9

Comparative in vitro activity of bay Y 3118, a new 4-quinolone, and ciprofloxacin against mycobacterium tuberculosis and M. avium complex

F.A. Sirgel, A. Venter, H.-D. Heilmann

Journal:

Tubercle and Lung Disease

Year:

1994

Language:

english

File:

PDF, 148 KB

english, 1994

10

Involvement of the katG and rpoB genes of M. tuberculosis in isoniazid and rifampicin resistant clinical isolates

T.C. Victor, G.S. Pretorius, F. Sirgel, P.D. Van Helden

Journal:

Tubercle and Lung Disease

Year:

1994

Language:

english

File:

PDF, 155 KB

english, 1994

11

073-PA11 Early bactericidal activity of ciprofloxacin in patients with pulmonary tuberculosis compared to that of isoniazid

F.J.H. Botha, F.A. Sirgel, B.W. van de Wal, D.P. Parkin, P.R. Donald, R. Schall, D.A. Mitchison

Journal:

Tubercle and Lung Disease

Year:

1995

Language:

english

File:

PDF, 125 KB

english, 1995

12

The clinical relevance of Mycobacterial pharmacogenetics

R.M. Warren, E.M. Streicher, N.C. Gey van Pittius, B.J. Marais, G.D. van der Spuy, T.C. Victor, F. Sirgel, P.R. Donald, P.D. van Helden

Journal:

Year:

2009

Language:

english

File:

PDF, 147 KB

english, 2009

13

Life cycle ofRenylaima capensis, a brachylaimid trematode of shrews and slugs in South Africa: two-host and three-host transmission modalities suggested by epizootiology and DNA sequencing

Wilhelm F Sirgel, Patricio Artigas, M Dolores Bargues, Santiago Mas-Coma

Journal:

Parasites & Vectors

Year:

2012

Language:

english

File:

PDF, 868 KB

english, 2012

14

embB 306 Mutations as Molecular Indicators to Predict Ethambutol Susceptibility in Mycobacterium tuberculosis

Sirgel, Frederick A., Warren, Robin M., Streicher, Elizabeth M., Victor, Thomas C., van Helden, Paul D., Böttger, Erik C.

Journal:

Year:

2012

Language:

english

File:

PDF, 146 KB

english, 2012

15

Mutations in the rrs A1401G Gene and Phenotypic Resistance to Amikacin and Capreomycin in Mycobacterium tuberculosis

Sirgel, Frederick A., Tait, Marisa, Warren, Robin M., Streicher, Elizabeth M., Böttger, Erik C., van Helden, Paul D., Gey van Pittius, Nicolaas C., Coetzee, Gerrit, Hoosain, Ebrahim Y., Chabula-Nxiwen

Journal:

Microbial Drug Resistance

Year:

2012

Language:

english

File:

PDF, 192 KB

english, 2012

16

Early bactericidal activity of antituberculosis agents

Donald, PR, Sirgel, FA, Venter, A, Parkin, DP, Seifart, HI, Wal, BW van de, Maritz, JS, Fourie, PB

Journal:

Expert Review of Anti-infective Therapy

Year:

2003

Language:

english

File:

PDF, 244 KB

english, 2003

17

Evaluation of the AID TB Resistance Line Probe Assay for Rapid Detection of Genetic Alterations Associated with Drug Resistance in Mycobacterium tuberculosis Strains

Ritter, C., Lucke, K., Sirgel, F. A., Warren, R. W., van Helden, P. D., Bottger, E. C., Bloemberg, G. V.

Journal:

Journal of Clinical Microbiology

Year:

2014

Language:

english

File:

PDF, 566 KB

english, 2014

18

Moxifloxacin Retains Antimycobacterial Activity in the Presence of gyrA Mutations

McGrath, M., Gey van Pittius, N. C., Sirgel, F. A., Van Helden, P. D., Warren, R. M.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2014

Language:

english

File:

PDF, 426 KB

english, 2014

19

A New Species of Oopeltidae (Mollusca, Pulmonata, Arionoidea), with a Revision of the Subfamily Ariopeltinae and Remarks on its Affinities within the Family and Superfamily

Journal:

African Invertebrates

Year:

2012

Language:

english

File:

PDF, 1.12 MB

english, 2012

20

Impact of Nonlinear Interactions of Pharmacokinetics and MICs on Sputum Bacillary Kill Rates as a Marker of Sterilizing Effect in Tuberculosis

Chigutsa, Emmanuel, Pasipanodya, Jotam G., Visser, Marianne E., van Helden, Paul D., Smith, Peter J., Sirgel, Frederick A., Gumbo, Tawanda, McIlleron, Helen

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 1.25 MB

english, 2015

21

A multicentre study of the early bactericidal activity of anti-tuberculosis drugs

Sirgel, F. A., Donald, P. R., Odhiambo, J., Githui, W., Umapathy, K. C., Paramasivan, C. N., Tam, C. M., Kam, K. M., Lam, C. W., Sole, K. M., Mitchison, D. A.

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2000

Language:

english

File:

PDF, 100 KB

english, 2000

22

Mutations in katG gene sequences in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis are rare

Pretorius, G. S., van Helden, P. D., Sirgel, F., Eisenach, K. D., Victor, T. C.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

1995

Language:

english

File:

PDF, 507 KB

english, 1995

23

The early bactericidal activity of rifabutin in patients with pulmonary tuberculosis measured by sputum viable counts: a new method of drug assessment

Sirgel, Frederick A., Botha, Frederik J. H., Parkin, Donald P., Van De Wal, Bernard W., Donald, Peter R., Clark, Peter K., Mitchison, Denis A.

Journal:

Journal of Antimicrobial Chemotherapy

Year:

1993

Language:

english

File:

PDF, 515 KB

english, 1993

24

The pyrazinamide susceptibility breakpoint above which combination therapy fails

Gumbo, T., Chigutsa, E., Pasipanodya, J., Visser, M., van Helden, P. D., Sirgel, F. A., McIlleron, H.

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2014

Language:

english

File:

PDF, 269 KB

english, 2014

25

Genome and MIC stability in Mycobacterium tuberculosis and indications for continuation of use of isoniazid in multidrug-resistant tuberculosis

VICTOR, T. C., WARREN, R., BUTT, J. L., JORDAAN, A. M., FELIX, J. V., VENTER, A., SIRGEL, F. A., SCHAAF, H. S., DONALD, P. R., RICHARDSON, M., CYNAMON, M. H., VAN HELDEN, P. D.

Journal:

Journal of Medical Microbiology

Year:

1997

Language:

english

File:

PDF, 2.20 MB

english, 1997

26

The Influence of Human N-Acetyltransferase Genotype on the Early Bactericidal Activity of Isoniazid

Donald, P. R., Sirgel, F. A., Venter, A., Parkin, D. P., Seifart, H. I., van de Wal, B. W., Werely, C., van Helden, P. D., Maritz, J. S.

Journal:

Clinical Infectious Diseases

Year:

2004

Language:

english

File:

PDF, 105 KB

english, 2004

27

Phage C-1: an IncC Group Plasmid-specific Phage

SIRGEL, F. A., COETZEE, J. N., HEDGES, R.W., LECATSAS, G.

Journal:

Microbiology (Society for General Microbiology)

Year:

1981

Language:

english

File:

PDF, 2.66 MB

english, 1981

28

Genetic Recombination in Fused Spheroplasts of Providence alcalifaciens

COETZEE, J. N., SIRGEL, F. A., LECATSAS, G.

Journal:

Journal of General Microbiology

Year:

1979

Language:

english

File:

PDF, 1.42 MB

english, 1979

29

Early Bactericidal Activity of Paromomycin (Aminosidine) in Patients with Smear-Positive Pulmonary Tuberculosis

Donald, P. R., Sirgel, F. A., Kanyok, T. P., Danziger, L. H., Venter, A., Botha, F. J., Parkin, D. P., Seifart, H. I., Van de Wal, B. W., Maritz, J. S., Mitchison, D. A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2000

Language:

english

File:

PDF, 54 KB

english, 2000

30

Isoniazid Activity Is Terminated by Bacterial Persistence

Mitchison, Denis A., Jindani, Amina, Davies, Geraint R., Sirgel, Frederik

Journal:

The Journal of Infectious Diseases

Year:

2007

Language:

english

File:

PDF, 53 KB

english, 2007

31

Moxifloxacin Population Pharmacokinetics and Model-Based Comparison of Efficacy between Moxifloxacin and Ofloxacin in African Patients

Zvada, S. P., Denti, P., Sirgel, F. A., Chigutsa, E., Hatherill, M., Charalambous, S., Mungofa, S., Wiesner, L., Simonsson, U. S. H., Jindani, A., Harrison, T., McIlleron, H. M.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2014

Language:

english

File:

PDF, 646 KB

english, 2014

32

The Early Bactericidal Activities of Rifampin and Rifapentine in Pulmonary Tuberculosis

Sirgel, Frik A., Fourie, P. Bernard, Donald, Peter R., Padayatchi, Nesri, Rustomjee, Roxana, Levin, Jonathan, Roscigno, Giorgio, Norman, Jennifer, McIlleron, Helen, Mitchison, Denis A.

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

2005

Language:

english

File:

PDF, 123 KB

english, 2005

33

Diversity and distribution of nematodes associated with terrestrial slugs in the Western Cape Province of South Africa

Ross, J.L., Ivanova, E.S., Sirgel, W.F., Malan, A.P., Wilson, M.J.

Journal:

Journal of Helminthology

Year:

2012

Language:

english

File:

PDF, 98 KB

english, 2012

34

Properties of a Filamentous Phage which Adsorbs to Pili Coded by Plasmids of the IncI Complex

Coetzee, J. N., Sirgel, F. A., Lecatsas, G.

Journal:

Microbiology (Society for General Microbiology)

Year:

1980

Language:

english

File:

PDF, 763 KB

english, 1980

35

Sources of variation in studies of the early bactericidal activity of antituberculosis drugs

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2001

Language:

english

File:

PDF, 81 KB

english, 2001

36

Early bactericidal activity as a method of assessment of drugs for the treatment of tuberculosis

SIRGEL, F.A., BOTHA, F.J. H., PARKIN, D. P., DE WAL, B. W. VAN, DONALD, P. R., MITCHISON, D. A.

Journal:

Journal of Antimicrobial Chemotherapy

Year:

1994

Language:

english

File:

PDF, 169 KB

english, 1994

37

Comparative in-vitro activity of Bay y 3118, a new quinolone, and ciprofloxacin against Mycobacterium tuberculosis and Mycobacterium avium complex

SIRGEL, F. A., VENTER, A., HEILMANN, H.-D.

Journal:

Journal of Antimicrobial Chemotherapy

Year:

1995

Language:

english

File:

PDF, 211 KB

english, 1995

38

Emergence and Spread of Extensively and Totally Drug-Resistant Tuberculosis, South Africa

Klopper, Marisa, Warren, Robin Mark, Hayes, Cindy, Gey van Pittius, Nicolaas Claudius, Streicher, Elizabeth Maria, Müller, Borna, Sirgel, Frederick Adriaan, Chabula-Nxiweni, Mamisa, Hoosain, Ebrahim,

Journal:

Emerging Infectious Diseases

Year:

2013

Language:

english

File:

PDF, 819 KB

english, 2013

39

The Early Bactericidal Activity of Ciprofloxacin in Patients with Pulmonary Tuberculosis

SIRGEL, FREDERICK A., BOTHA, FREDERICK J., PARKIN, DONALD P., VAN de WAL, BERNARD W., SCHALL, ROBERT, DONALD, PETER R., MITCHISON, DENIS A.

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

1997

Language:

english

File:

PDF, 54 KB

english, 1997

40

The Early Bactericidal Activity of Isoniazid Related to Its Dose Size in Pulmonary Tuberculosis

DONALD, PETER R., SIRGEL, FREDERICK A., BOTHA, FREDERICK J., SEIFART, HEINER I., PARKIN, DONALD P., VANDENPLAS, MICHEL L., VAN de WAL, BERNARD W., MARITZ, JOHANNES S., MITCHISON, DENIS A.

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

1997

Language:

english

File:

PDF, 68 KB

english, 1997

41

Low Frequency of Acquired Isoniazid and Rifampicin Resistance in Rifampicin-Susceptible Pulmonary Tuberculosis in a Setting of High HIV-1 Infection and Tuberculosis Coprevalence

Rockwood, Neesha, Sirgel, Frederick, Streicher, Elizabeth, Warren, Robin, Meintjes, Graeme, Wilkinson, Robert J

Journal:

The Journal of Infectious Diseases

Year:

2017

Language:

english

File:

PDF, 707 KB

english, 2017

42

Concentration-Dependent Antagonism and Culture Conversion in Pulmonary Tuberculosis

Rockwood, Neesha, Pasipanodya, Jotam G., Denti, Paolo, Sirgel, Frederick, Lesosky, Maia, Gumbo, Tawanda, Meintjes, Graeme, McIlleron, Helen, Wilkinson, Robert J.

Journal:

Clinical Infectious Diseases

Year:

2017

Language:

english

File:

PDF, 903 KB

english, 2017

43

In vitro Investigation of the Antimicrobial Activities of Novel Tetramethylpiperidine- Substituted Phenazines against Mycobacterium tuberculosis

van Rensburg, Constance E.J., Jooné, Gisela K., Sirgel, Frederick A., Matlola, Nthane M., O’Sullivan, John F.

Journal:

Year:

2000

Language:

english

File:

PDF, 297 KB

english, 2000

44

High Frequency of Resistance, Lack of Clinical Benefit, and Poor Outcomes in Capreomycin Treated South African Patients with Extensively Drug-Resistant Tuberculosis

Pietersen, Elize, Peter, Jonny, Streicher, Elizabeth, Sirgel, Frik, Rockwood, Neesha, Mastrapa, Barbara, Te Riele, Julian, Davids, Malika, van Helden, Paul, Warren, Robin, Dheda, Keertan, Tyagi, Anil

Journal:

Year:

2015

Language:

english

File:

PDF, 209 KB

english, 2015

45

Correction: The Rationale for Using Rifabutin in the Treatment of MDR and XDR Tuberculosis Outbreaks

Sirgel, Frederick A., Warren, Robin M., Böttger, Erik C., Klopper, Marisa, Victor, Thomas C., van Helden, Paul D.

Journal:

Year:

2015

Language:

english

File:

PDF, 120 KB

english, 2015

46

Characteristics and Classification of IncC Group Plasmid-Dependent Phage C-1

Sirgel, F.A., Coetzee, W.F.

Journal:

Year:

1983

Language:

english

File:

PDF, 760 KB

english, 1983

47

Nematodes associated with terrestrial slugs from canola fields and ornamental nurseries in South Africa

PIETERSE, ANNIKA, MALAN, ANTOINETTE P., KRUITBOS, LAURA M., SIRGEL, WILLEM, ROSS, JENNA L.

Journal:

Year:

2017

Language:

english

File:

PDF, 176 KB

english, 2017

48

The potential use of rifabutin for treatment of patients diagnosed with rifampicin-resistant tuberculosis

Whitfield, Michael G, Warren, Robin M, Mathys, Vanessa, Scott, Lesley, De Vos, Elise, Stevens, Wendy, Streicher, Elizabeth M, Groenen, Guido, Sirgel, Frederick A, Van Rie, Annelies

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2018

Language:

english

File:

PDF, 252 KB

english, 2018

49

Emergence and Spread of Extensively and Totally Drug-Resistant Tuberculosis, South Africa

Klopper, Marisa, Warren, Robin Mark, Hayes, Cindy, Gey van Pittius, Nicolaas Claudius, Streicher, Elizabeth Maria, Müller, Borna, Sirgel, Frederick Adriaan, Chabula-Nxiweni, Mamisa, Hoosain, Ebrahim,

Journal:

Emerging Infectious Diseases

Year:

2013

Language:

english

File:

PDF, 1.48 MB

english, 2013

50

Minority Mycobacterium tuberculosis Genotypic Populations as an Indicator of Subsequent Phenotypic Resistance

Engelthaler, David M., Streicher, Elizabeth M., Kelley, Erin J., Allender, Christopher J., Wiggins, Kristin, Jimenez, Dulce, Lemmer, Darrin, Vittinghoff, Eric, Theron, Grant, Sirgel, Frederick A., War

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2019

File:

PDF, 535 KB

2019

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